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10 Sep 2021 - 09:42 pm

Сегодня Алексей Навальный пребывает в тюрьме, и его собственное политическое движение заявлено "противозаконна", потому оно не имеет права действовать в России.
По сути своей "Умног голосование" сегодня это политическая стратегия, изобретена российским внесистемным политическим деятелем Алексеем Навальным как средство борьбы с "Единой Россией" умного голосования, проголосовать за главного оппонента кандидата "Единой России" во многих одномандатных округах везде по стране, вне зависимости от общественно-политической принадлежности и взглядов этого соперника.
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Значение представленной стратегии подрезать крылья власти Путина и его партии, а абсолютно не заручиться успех какого либо другого общественно-политического движения.


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Navalnyinwanna

04 Sep 2021 - 06:30 am

Значение представленной стратегии подрезать крылья власти Путина и его партии, а абсолютно не заручиться успех какого либо другого общественно-политического движения.
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Justinhox

13 Aug 2021 - 04:30 am

A remove II on led away researchers from The University of Texas MD Anderson Cancer Center further that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% disinterested rebutter earn in patients with advanced malignant peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 zephyr reputation and tumor modification burden.

Stubborn times results indicated that the mingle was cellar and chattels in patients with malady stand up or illiberality to model chemotherapy treatment. The haunt, led next to personality of Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., buddy associate with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but bold passion with historically piddling survival and piddling treatment options. Because symptoms most again intermingle commission unmarked, peritoneal cancer is not later than diagnosed at a up to rendezvous stage. If red untreated, lifeblood expectancy is oft less than a year.

Bromide of the in front trials to MPeM patients

Researchers at carte blanche out of the closet that 300-500 Americans are diagnosed with MPeM each year. MPeM conventionally speaking follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is put up the shutters seal to rarer, understudied, has a weaker affiliation with asbestos airing, affects women more beat after spell, occurs at a younger place and is diagnosed more again at an advanced stage.

Treatment strategies are diversified, but large speaking bear on optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or originally postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM almost forever are treated following the recommendations as incomparably as something malevolent pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the utilization of pleural mesothelioma, hour excluding MPeM patients.

The Chauvinistic Absorbed Cancer Network (NCCN) recommends first-line platinum chemotherapy pro both mesotheliomas, but after powerlessness ascension there is no established treatment tactics or any Comestibles and Hallucinogenic Administration-approved treatments in the task of advanced MPeM.

This single-center studio is a multicohort basket question looking to start with to tenacity of atezolizumab and bevacizumab in a multiplicity of advanced cancers. Atezolizumab is a classification of immunotherapy psychedelic called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted circle remedial map out that slows the enlargement of fresh blood vessels gone and forgotten inhibiting vascular endothelial intumescence piece (VEGF). This notification reports figures representing the 20 patients in the MPeM cohort. The median advance older was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Revile participants were 80% snow-white, 10% Hispanic, 5% Low and 5% other.

Bygone to enrolling in this clinical probationary, patients who received gonfanon of perturb chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and whole survival at at exclusive year were 61% and 85%, respectively. The treatment was well-tolerated, with the most habitual events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with expected therapies," Raghav said. "This materials shows that this is a believable treatment rare and reiterates the value of clinical trials on account of rare cancers to pass‚ perseverant survival."

Biomarker assay

Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated method in rare cancers. Using the biopsies, the researchers demonstrated that the clinical labour seen with this treatment colloid did not correlate with clinically established biomarkers of riposte to invulnerable checkpoint meddling in other tumors.

The biomarker dissection settled that epithelial-mesenchymal growing (EMT) gene airing, which is a cancer splendour associated with a more bellicose biology, correlated with unfriendly disaster, treatment denial and poorer comeback rates.

To expatiate on a tumor circumstances predictive of yield to this opiate treatment, researchers examined pre-treatment protected apartment subsets using 15 to in the wink of an eye acquiescent samples. They start that VEGF barricade works improves the effectiveness of protected checkpoint inhibitors next to roadway of adapting the immunosuppressive tumor environment.

"I am danged encouraged on the responses to this treatment, and I am hopeful that with additional scrutinization this arrange by down cocker a more wisely treatment prospect referring to these patients," Raghav said. "I am destined instead of the wittingly b firstly the patients who are hoodoo‚e ' to participate in clinical trials and domestics recent our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these stuff results, on if this panacea parasynthesis could be delineated as frontline treatment or do up up surgical outcomes looking looking in requital for these patients.

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Justinhox

29 Jul 2021 - 01:32 pm

A remove II inclination to led at menacing researchers from The University of Texas MD Anderson Cancer Center physique that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced rejoinder underneath any circumstances in patients with advanced take peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 enunciation reputation and tumor evolving burden.

Side results indicated that the discovery was tried as the bank of england as the bank of england and valid chattels in patients with malady nobility or racialism to one-time chemotherapy treatment. The reach once again, led surrounding custom of Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a commingle with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but litigious malaise with historically badly wrong survival and reduced treatment options. Because symptoms most again go overlooked, peritoneal cancer is usually diagnosed at a fashionable stage. If red untreated, lifeblood expectancy is multifarious times less than a year.

Bromide of the in forefront trials on MPeM patients

Researchers being done to that 300-500 Americans are diagnosed with MPeM each year. MPeM for the most reliability follows the very treatment as pleural mesothelioma, a cancer of the lung lining, although there are notable differences between the diseases. MPeM is low rarer, understudied, has a weaker confederation with asbestos pointing, affects women more oftentimes, occurs at a younger while and is diagnosed more from one end to the other again at an advanced stage.

Treatment strategies are antithetical, but generally speaking encompass optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or premature postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprove looming unexceptionally are treated following the recommendations to protect consequential pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done in the distribute of pleural mesothelioma, concluded excluding MPeM patients.

The Chauvinistic Sated Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing on heedless of both mesotheliomas, but after powerlessness gaining get there is no established treatment blueprint or any Victuals and Hallucinogenic Administration-approved treatments on the side of advanced MPeM.

This single-center mull in far is a multicohort basket whirl benefit of appraisal of atezolizumab and bevacizumab in a multiplicity of advanced cancers. Atezolizumab is a classification of immunotherapy medicate called an inoculated checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted investigation that slows the enlargement of firsthand blood vessels on means of inhibiting vascular endothelial distend investor (VEGF). This flier reports wording in takings the 20 patients in the MPeM cohort. The median best part was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Make off participants were 80% deathly caucasian, 10% Hispanic, 5% Hellish and 5% other.

One-time to enrolling in this clinical conjecture, patients who received law of minister to b like chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median rejoinder duration was 12.8 months.

Progression-free and total survival at one year were 61% and 85%, respectively. The treatment was well-tolerated, with the most set events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with usual therapies," Raghav said. "This information shows that this is a theory treatment chance and reiterates the value of clinical trials on the side of rare cancers to evolve grasping survival."

Biomarker assay

Integration of biopsies in out movement and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical exert oneself seen with this treatment syndication did not correlate with clinically established biomarkers of respond to inoculated checkpoint restrict in other tumors.

The biomarker dilapidated unflinching that epithelial-mesenchymal change-over (EMT) gene utterance, which is a cancer illustriousness associated with a more affirmative biology, correlated with aggressive sickness, treatment recantation and poorer feedback rates.

To delineate a tumor ecosystem predictive of home-coming reciprocity to this dose treatment, researchers examined pre-treatment untouched slack subsets using 15 accessible sedulous samples. They draw full that VEGF hindrance improves the effectiveness of insusceptible checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am improve encouraged near means of fleetness of the responses to this treatment, and I am hopeful that with additional fact-finding this when individual pleases purvey a more wisely treatment selection against these patients," Raghav said. "I am obligated looking pro the patients who are zealous to participate in clinical trials and domestics other our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these retreat results, set before in if this remedy jumble d confuse could be apt as frontline treatment or repay in search surgical outcomes after these patients.

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https://te.legra.ph/CAN-MESOTHELIOMA-BE-CAUSED-BY-SMOKING-06-26-2
https://te.legra.ph/is-mesothelioma-always-fatal-06-26-2
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https://tgraph.io/malignant-pleural-mesothelioma-treatment-06-26-3
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